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Results: Between October 4, 2018, and December 3, 2020, we randomly assigned 166 participants to short-term MBT ( n = 84) or long-term MBT ( n = 82). This trial was prospectively registered at, NCT03677037. All outcomes were primarily assessed at 16 months after randomization. Secondary outcomes were functional impairment, quality of life, global functioning, and severe self-harm. The primary outcome was BPD symptoms assessed with the Zanarini Rating Scale for Borderline Personality Disorder. Methods: Adult outpatients (≥18 years) with subthreshold or diagnosed BPD were randomly assigned (1:1) to short-term MBT (5 months) or long-term MBT (14 months). Objective: The aim of the study was to assess the efficacy and safety of short-term versus long-term MBT for outpatients with BPD. No previous trial has compared short-term with long-term MBT. Mentalization-based therapy (MBT) is an evidence-based intervention for BPD, and several countries offer treatment programs for BPD lasting for years, which is resource demanding. Introduction: Borderline personality disorder (BPD) is a severe and prevalent psychiatric disorder.
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